![]() Discrimination for clinically significant cancer was better when PSA density was added to a model with additional clinical information (AUC 0.75 vs. Main endpoint was clinically significant cancer defined as a Gleason Score of 7 or greater. 5,291 men in a population with PSA levels of 3 ng/mL or greater and ultrasound-guided prostate volume measurements, PSAD results were calculated. PSA density performed better than PSA alone above 4 ng/mL for detecting prostate cancer. Several studies have looked at the predictive properties of PSAD to help guide clinical decision making if biopsy is required or not. Potential causes for abnormally raised or lowered PSA levels are summarized in the table below: Raised PSA levels At PSA levels between 4 and 10 ng/mL (the borderline range), there is a 25% chance of cancer which increases to over 50% for PSA above 10 ng/mL. The higher the serum PSA (whilst there isn’t a set cut-off, 4 ng/mL is commonly used), the greater the likelihood of positive prostatic cancer diagnosis so this PSA level is used as indication for further testing.īut it was also found that about 15% of men with PSA below 4 may have prostate cancer, if biopsy performed. The prostate-specific antigen is a protein formed by both normal and cancer prostatic cells, usually found in semen but also in blood, in smaller quantities. ![]() Next step: Use the above in association with the Gleason Score, to prognosticate prostate cancer recurrence. developed a method to calculate prostate cancer volume. The cut-off of 0.15-0.20 ng/mL/cc is used to help guide clinical decision between a watch-and-wait or an invasive approach when managing prostate carcinoma. The Stanford Prostate Cancer Calculator (SPCC): Externally Validated Online Nomograms. 347 Preoperatiove prostate cancer volume estimation based on clinically correlated. Calculation by using the ellipsoid formula (length x width x height × /6). PSA density helps distinguish between Benign prostatic hyperplasia (BPH) and prostate cancer. Prostate volume estimation at MRI or Ultrasound and PSA-Density calculation. ![]() Prostate Density in ng/mL/cc = PSA / Volume. ![]()
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